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Canine Leukemia

Canine leukemia, or blood cancer in dogs, can be in many forms. The most common form of dog leukemia is lymphocytic leukemia.

Leukemia means "white blood" and, as a disease, refers to a condition where there is an abnormal increase in the number of white blood cells in the bloodstream or the bone marrow. It is a result of genetic mutation that alters the structure of the bone marrow, causing it to over-produce cancerous cells and under-produce other healthy blood cells that a dog needs.

There are several forms of canine leukemia and the disease is classified according to the type of cells involved and the developmental stage of the cancerous cells that are causing the disease.

Canine Leukemia

Lymphocytic leukemia involves lymph node cells, whereas myelogenous leukemia originates from the bone marrow. In dogs, lymphocytic leukemia is more common.

Both of these two forms of canine leukemia (lymphocytic leukemia and myelogenous leukemia) may either be acute or chronic, depending on how mature the cancer cells are.

Acute leukemia refers to the rapid and sudden increase in the number of immature blood cells (blood cells that are in their early stages of development).

The increase of these immature cancerous blood cells is so dramatic that it hinders the production of other healthy blood cells, posing an immediate threat to the dog patient's life.

Chronic leukemia refers to the abnormal increase in the number of more developed, mature blood cells. The increase is not sudden but rather is a build-up over months or even years. Chronic leukemia occurs more frequently in older dogs.

As a general rule, the acute forms of canine leukemia is more malignant than the chronic forms.

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Acute Lymphocytic Leukemia in Dogs

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As mentioned above, acute leukemia acts more malignantly than chronic leukemia. The cancerous blood cells can rapidly spread through the blood stream to other parts of the body such as the liver and the spleen. As well, since the bone marrow is so preoccupied with making these cancerous cells, there is an alarming lack of other healthy blood cells that a dog needs.

This acute form of canine leukemia usually affect middle-aged dogs or older (6 years or older), but younger dogs (under 4 years of age) can also be affected.

Signs of Acute Leukemia

Dogs with acute leukemia generally show some of the following signs:

  • Tendency to bleed or bruise easily (This is due to the high number of immature blood cells and lack of blood platelets that are responsible for blood clotting.)
  • A dysfunctional immune system resulting in recurrent infections and delay in healing time
  • Appetite loss
  • Weight loss
  • Lethargy
  • Pale gums
  • Diarrhea
  • Lameness

Treatment for Acute Leukemia

Dogs with acute leukemia may require chemotherapy in order to stop the growth of the cancerous blood cells. However, even with aggressive chemotherapy, only about 30 percent of dog patients can have remission. In many cases, the dogs' immune systems are so weak and dysfunctional as a result of the cancer that the chemotherapy drugs cause them to succumb to secondary diseases. Very often, more drugs (e.g. antibiotics) are needed to treat the secondary diseases. In addition to chemotherapy, many dogs need blood transfusions because of the severe anemia caused by the leukemia.

Without any type of treatment, most dog patients with acute leukemia die within a few weeks.

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Chronic Lymphocytic Leukemia in Dogs

Dog Leukemia

While acute leukemia is aggressive and can develop very rapidly, chronic leukemia takes months or even years to develop.

Chronic leukemia is usually diagnosed in older dogs (10 to 12 years of age).

About half of the dogs diagnosed with chronic leukemia show no symptoms and many of the dog patients can survive for up to two years without chemotherapy.

As well, while dog patients with acute leukemia do not respond well to chemotherapy, most dogs with chronic leukemia do well with chemotherapy.

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Causes of Canine Leukemia

There are no known causes of leukemia, although it is suspected that certain breeds may be genetically predisposed to it. Leukemia may also result from radiation, certain chemicals and viruses.

Diagnosis of Canine Leukemia

Appropriate laboratory finding are critical to diagnosis of leukemia, because as you can see above, some of the symptoms of leukemia are rather indistinct and are similar to those of many other diseases (e.g. severe bacterial infection; severe inflammatory conditions such as pancreatitis; autoimmune disease, lymphoma).

Diagnosis of dog leukemia include the following tests:

  • Complete blood count
  • Biochemical profile
  • Urinalysis
  • Chest and abdominal x-rays
  • Abdominal ultrasound
  • Bone marrow aspirate
  • Fine needle aspirate of abdominal organs or lymph nodes

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Natural Remedies for Canine Leukemia

Although natural remedies such as herbs, homeopathic remedies, and natural supplements may not be able to destroy tumors, they are nonetheless effective in strengthening the immune system, making the body stronger to fight against diseases such as cancer.

Some dog parents have reported success in using the herbal formula "Essiac" to treat canine cancer, while others swear by such remedies as the "Budwig Diet". For more information on these and other natural remedies for canine cancer, please visit our pages on Herbs for Cancer in Dogs and Dog Cancer Diet.



Related Topics

Dog Cancer
Symptoms of Dog Cancer
Conventional Cancer Treatment for Dog Patients
Herbs for Cancer in Dogs
Dog Cancer Diet

References

S. Messonnier, The Natural Vet's Guide to Preventing and Treating Cancer in Dogs (New World Library, 2006).
A.D. Shojai, New Choices in Natural Healing for Dogs and Cats (Rodale Press, Inc., 1999).

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