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Lymphoma in Dogs (Canine Lymphosarcoma)

Lymphoma in dogs is a common type of canine cancer, making up about 7 to 25 percent of all dog cancers.

Canine lymphoma (or canine lymphosarcoma) is a malignant cancer of the lymphocytes. (Lymphocytes are cells in the lumphatic system which are responsible for mounting an immune response. Two main types are B cells and T cells.)

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Dog lymphoma can occur in:

  • the lymph nodes (most commonly seen);
  • in the skin;
  • in the stomach, intestines, liver, and spleen.

Lymphoma in dogs can also occur in other less common sites, such as the bone marrow, the nervous system, nasal cavity, or kidneys.

The cancer can be aggressive and can rapidly ruin the health of the internal organs. If left untreated, it can become life threatening to the dog patient in less than eight weeks.

Signs of Lymphoma in Dogs

Lymphoma in Dogs

Clinical signs of canine lymphoma depend on the location of the tumor(s), and the extent to which the disease has developed.

For tumors that occur in the lymph nodes, we can notice a painless enlargement of the dog patient's lymph nodes, with no other symptoms. The dog usually does not feel sick. Sometimes the affected lymph nodes will enlarge, then shrink back to normal size, then enlarge again.

For lymphoma that occurs in the stomach or intestines, the dog patient may show signs that are typical of gastrointestinal problems, such as:

Lymphoma that occurs in the skin can present itself in several different ways, including single or multiple lumps in the skin, or mouth. These lesions can be red, itchy, and ulcerated.

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Causes of Lymphoma in Dogs

The exact cause of canine lymphosarcoma is unknown, although there seems to be increased risk in dogs who have been exposed to the herbicide 2,4-D. Other possible causes include exposure to strong magnetic fields, or genetic predisposition.

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Risk Factors for Lymphoma in Dogs

Age

Canine lymphosarcoma occurs more commonly among middle-aged to older dogs. In fact, most affected dogs are between 5-9 years of age.

Breeds

The following breeds of dogs tend to have a higher risk of developing canine lymphosarcoma:

  • Golden retrievers;
  • Labrador retrievers;
  • Boxers;
  • Rottweilers;
  • Scottish terriers;
  • Airedale terriers;
  • St. Bernards;
  • Bulldogs;
  • Basset hounds.

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Diagnosis of Lymphoma in Dogs

Depending on the location of the tumor, canine lymphoma is diagnosed using a combination of tests, such as blood tests, fine needle aspirates of the tumor, biopsies, x-rays and ultrasound.

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Treatment for Lymphoma in Dogs

Canine Lymphosarcoma

Since canine lymphosarcoma is considered a systemic or whole body disease and may strike in any location, surgery is ineffective and impractical.

The treatment of choice is chemotherapy which usually consists of a combination of oral and injectable drugs given on a weekly basis. Some commonly used anticancer medications for canine lymphosarcoma include Elspar, Cytoxan, Oncovin, Adriamycin, and prednisone. While undergoing chemotherapy, regular blood tests should be carried out to monitor for decreased white blood cell counts (drug-induced myelosuppresion).

For the same reason as surgery, radiation is not commonly recommended for lymphoma in dogs. However, relatively novel approaches have recently been adopted to treat canine lymphosarcoma. For example, the dog patient may receive half-body irradiation - each half body is treated 4 weeks apart. Also, radiation to a single lymph node or all nodes may be given to dog patients that are drug-resistant.

Most dogs with lymphoma are rather responsive to chemotherapy. Greater than 75% of dogs with lymphoma are expected to achieve a complete remission of 6 to 11 months with chemotherapy. When a dog treated with chemotherapy comes out of remission, further chemotherapy (rescue protocol) can be given which may induce second or even third remissions. However, understand that cancer cells that have survived prior chemotherapy treatments are stronger and more resistant to being eradicated; therefore, stronger and stronger medications have to be used. Dog parents, at that stage, have to make a decision as to whether it is in their dogs' best interest to have more rounds of treatment or whether euthanasia is a better option.

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Natural Remedies for Lymphoma in Dogs

Although natural remedies such as herbs, homeopathic remedies, and natural supplements may not be able to destroy tumors, they are nonetheless effective in strengthening the immune system, making the body stronger to fight against diseases such as cancer.

Some dog parents have reported success in using the herbal formula "Essiac" to treat canine cancer, while others swear by such remedies as the "Budwig Diet".

For more information on these and other natural remedies for canine cancer, please visit our pages on Herbs for Cancer in Dogs and Dog Cancer Diet.



Related Topics

Dog Cancer
Symptoms of Dog Cancer
Conventional Cancer Treatment for Dog Patients
Herbs for Cancer in Dogs
Dog Cancer Diet

References

S. Messonnier, The Natural Vet's Guide to Preventing and Treating Cancer in Dogs (New World Library, 2006).
A.D. Shojai, New Choices in Natural Healing for Dogs and Cats (Rodale Press, Inc., 1999).

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